The basophilic granulocyte.
نویسندگان
چکیده
منابع مشابه
Synergistic effects of nerve growth factor and granulocyte-macrophage colony-stimulating factor on human basophilic cell differentiation.
We have recently shown that nerve growth factor (NGF) promotes human granulopoiesis, specifically augmenting basophilic cell differentiation observed in methylcellulose hematopoietic colony assays of human peripheral blood. Because the NGF effect was seen in the presence of conditioned medium derived from a human T-cell line (Mo-CM) containing granulocyte-macrophage colony-stimulating factor (G...
متن کاملSodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60.
Sodium butyrate induces basophilic differentiation of HL-60 promyelocytic leukemia cells that have been previously passaged in alkaline medium. A factor present in Mo conditioned medium (Mo-CM) acts synergistically with sodium butyrate to promote basophilic maturation in a dose-dependent fashion. The induced HL-60 cells exhibit nuclei at various stages of maturity and cytoplasmic granules stain...
متن کاملStudies on desoxyribonuclease in systemic lupus erythematosus; non-participation of serum desoxyribonuclease in the L.E. phenomenon.
In 1948, Hargraves, Richmond, and Morton (1) described a new cellular element in the bone marrow of patients with acute systemic lupus erythematosus. This element, referred to as the "L.E. cell," has been confirmed by a number of investigators, and has been suggested as a diagnostic aid (2). The L.E. cell may be formed during the incubation of normal homologous or heterologous leucocytes (3) wi...
متن کاملIdentification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants.
Acute basophilic leukemia (ABL) is a rare subtype of acute leukemia with clinical features and symptoms related to hyperhistaminemia because of excessive growth of basophils. No known recurrent cytogenetic abnormality is associated with this leukemia. Rare cases of t(X;6)(p11;q23) translocation have been described but these were sporadic. We report here 4 cases of ABL with a t(X;6)(p11;q23) tra...
متن کاملShuang-Huang-Lian prevents basophilic granulocyte activation to suppress Th2 immunity
BACKGROUND Basophilic granulocytes (BGs) not only initiate the induction of Th2 cell differentiation, but also amplify the ongoing Th2 response. Shuang-Huang-Lian (SHL) is clinically used for relieving type I hypersensitivity by continuous treatment for several weeks. METHODS ELISA, flow cytometry, magnetic activated cell sorting, isoelectric precipitation, hybridoma technique, transfection a...
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عنوان ژورنال:
- Blood
دوره 14 5 شماره
صفحات -
تاریخ انتشار 1959